Cheapest · Used 2021 Mercedes-Benz S-Class
Rank #1 / 109 listings
Cheapest Used 2021 Mercedes-Benz S-Class for Sale in the US
The cheapest used 2021 Mercedes-Benz S-Class in the US today costs $44,995 — a 2021 S580-4m located in Wayne, MI. We track 109 active listings; the median price is $62,411, so the top deal is $17,416 under the median.
Browse by model year
cheapest per year- All years
- 2026 · from $119,144
- 2025 · from $85,488
- 2024 · from $53,990
- 2023 · from $7,370
- 2022 · from $37,450
- 2021 · from $44,995
- 2020 · from $25,322
- 2019 · from $18,444
- 2018 · from $16,202
- 2017 · from $2,099
- 2016 · from $14,990
- 2015 · from $10,900
- 2014 · from $12,500
- 2013 · from $7,599
- 2012 · from $7,995
- 2011 · from $4,995
- 2010 · from $5,300
- 2009 · from $4,995
- 2008 · from $3,999
- 2007 · from $4,500
- 2006 · from $3,800
- 2005 · from $3,000
- 2004 · from $4,495
- 2003 · from $3,900
- 2002 · from $3,999
- 2001 · from $2,900
- 2000 · from $2,990
Top 10 cheapest listings
ranked by price-
$44,9952021 Mercedes-Benz S-Class S580-4m90,100 mi · Wayne, MI · Road Runner Auto SalesView listing → -
$47,4002021 Mercedes-Benz S-Class S580-4m71,279 mi · Roswell, GA · Motorpoint RoswellView listing → -
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$51,0002021 Mercedes-Benz S-Class S580-4m51,393 mi · Bronx, NY · Eastchester Chrysler Jeep Dodge RamView listing → -
$51,8802021 Mercedes-Benz S-Class S580-4m76,639 mi · North Richland Hills, TX · AutoNation Chevrolet North Richland HillsView listing → -
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$52,2902021 Mercedes-Benz S-Class S580-4m59,074 mi · Wesley Chapel, FL · Jacobs Mitsubishi Wesley ChapelView listing → -
$52,3132021 Mercedes-Benz S-Class S580-4m70,493 mi · Barrington, IL · Motor Werks Barrington AutomallView listing → -
$52,5152021 Mercedes-Benz S-Class S580-4m59,074 mi · Wesley Chapel, FL · Jacobs Mitsubishi Wesley ChapelView listing → -
$52,8222021 Mercedes-Benz S-Class S580-4m62,754 mi · Westlake Village, CA · Shaver Chrysler Dodge Jeep RamView listing →
Deals on the map
10 pinnedFAQ
How much does the cheapest used 2021 Mercedes-Benz S-Class cost?
$44,995 — a 2021 S580-4m in Wayne, MI (as of 2026-07-19).
What is the median price of a used 2021 Mercedes-Benz S-Class?
$62,411 across 109 US dealer active listings.
How often are prices updated?
Listings and prices refresh continuously; this page is re-generated at least twice a day.
Explore more
Prices updated 2026-07-19. Data covers active dealer listings across the USA.